Inarecentstudy,investigatorsfromWashingtonUniversitySch...

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In a recent study, investigators from Washington University School of Medicine found that a small group of fat people don’t have common metabolic abnormalities （新陳代謝異常） associated with obesity.

Researchers followed 20 fat participants who were asked to gain about 15 pounds over several months to determine how the extra pounds affected their metabolic functions.

"Our goal is to have research participants consume 1,000 extra calories every day until each gains 6% of his or her body weight," said Elisa Fabrini, assistant professor of medicine. "This wasn’t easy to do. It’s just as difficult to get people to gain weight as it’s to get them to lose weight. "

All of the subjects gained weight by eating at fast food restaurants, under the supervision of a dietitian. Before and after weight gain, the researchers carefully evaluated （評估） each study subject’s ability to regulate blood sugar, liver fat, and other measures of metabolic health.

After gaining weight, the metabolisms of fat subjects remained normal if they were in the normal range when the study began. However, the metabolisms significantly worsened after weight gain in fat subjects whose metabolisms already were abnormal when the study got underway.

"This research shows that some fat people are protected from the negative metabolic effects of moderate weight gain, whereas others tend to develop these problems, "said senior investigator Samuel Klein.

As part of the study, the researchers then helped the subjects lose the weight they’d gained. In the investigation, researchers discovered some key factors that distinguished metabolically normal fat subjects from those with problems. One was the presence of fat inside the liver. Those with abnormal metabolisms accumulated （積累） fat there. Another difference involved gene function in fat tissue. People with normal metabolisms in spite of their obesity expressed more genes that regulate fat production and accumulation.

"These results suggest that the ability of body fat to expand and increase in a healthy way may protect some people from the metabolic problems associated with obesity and weight gain," said Klein.

33. In the study, a subject of 260 pounds should be asked to gain_________.

34. Some fat people can be protected from metabolic abnormalities because_________.

35. What should be the best title for the passage?

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