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Conclusion Naloxone has a significant role in relieving the central and peripheral circulation inhibition caused by endogenous opioid peptides in traumatic brain injury.

In this review, the distribution and physiologic functions of endogenous opioid peptides in hypothalamus were discussed.

Effects of κ-opioid peptide on hypoxic pulmonary hypertension

It is suggested that the endogenous opioid peptidergic system might act as an important modulatory system between CNS and the immune system.

The results suggest that leucine-enkephalin is probably involved in the pathophysiology of cerebral ischemia, and that hemodilution therapy may take effect by regulating endogenous opioid peptides.

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